In a controversial move, the U.S. Public Health Service has recommended varenicline (Chantix) as a smoking cessation drug, despite its recent links to depression and suicidal behavior. The new guidelines also mention other options and recommend counseling in conjunction with medication.

Authors of the guidelines analyzed 83 studies and found that varenicline helped 33% stay off tobacco for six months, compared to about 14% who were given a placebo.

Guidelines say the medication is not proven effective with some groups. The report recommends doctors consider asking about their patients' psychiatric history before prescribing it, but also closely monitor them for changes in mood and behavior.

Associated Press. "Chantix recommended to quit smoking despite safety concerns." 2008. ap.google.com/article/ALeqM5g2KJO6y54DpeceGpvfPM6nVa9b6QD90H4A2G0 (9 May 2008).