MOST EXPERTS AGREE that women who test positive for a breast cancer (BRCA) mutation—a genetic mutation that dramatically increases the risk
of breast cancer—should begin mammography screening well before the normally recommended age of 40. But a new study suggests
that BRCA carriers also need to consider the possible effects of cumulative radiation from multiple mammograms.
The study, published in The Journal of the National Cancer Institute, used mathematical modeling to determine that the risk of developing breast cancer from cumulative radiation exposure outweighs
or neutralizes the benefit of mortality reduction for early screening for BRCA mutation carriers ages 25 to 34. At age 35,
however, the risk/benefit ratio switches, leading the study authors to suggest that age 35 may be the best time for BRCA carriers
to start yearly mammograms.
Encourage any young BRCA carrier to discuss breast cancer screening with a breast care specialist. Additional screening, such
as ultrasound or MRI, may also be warranted.
Jennifer L.W. Fink, RN, BSN Reference
Berrington de Gonzalez A, Berg CD, Visvanathan K, Robson M. Estimated risk of radiation-induced breast cancer from mammographic
screening for young BRCA mutation carriers. J Natl Cancer Inst. 2009;101(3):205-209.
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